We proved that the natural activity of the immune system can protect nerve cells against degeneration and also help in recovery following CNS (Central nerves system) trauma
Technology
Proneuron Biotechnologies is enrolling patients suffering from complete spinal cord injuries to participate in a Phase II multi-center clinical study. Patients within 14 days of injury will be implanted with ProCord. Proneuron Biotechnologies, a Delaware company, is in advanced stages of clinical development in a number of attractive neurological markets. Proneuron is the first company to harness the power of the body's own immune system for the treatment of debilitating central nervous system (CNS) disorders. The concept of helping the body to "cure" itself, offers hope to the millions of victims of nervous system-related disorders. Proneuron Biotechnologies is developing therapies for neurological disorders, including spinal cord injury (SCI), other central nervous system trauma and back injuries. Our products are based on proprietary technology for modulating the interaction between the nervous system and the immune system. Proneuron is enrolling a total of 61 patients suffering from complete spinal cord injuries in a Phase II multi-center clinical study. Patients will be implanted with ProCord. Study sites must be informed of a candidate patient within a few days of the spinal cord injury to allow time to complete the necessary tests and procedures within 14 days of injury.
We proved that the natural activity of the immune system can protect nerve cells against degeneration and also help in recovery following CNS (Central nerves system) trauma
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Spinal cord Technology - General Information
Proneuron's proprietary therapeutic strategies for Spinal Cord Injuries are based on the intensive research of Prof. Michal Schwartz, Chair of Neuroimmunology at the Weizmann Institute of Science, Israel. Prof. Schwartz has shown that the natural activity of the immune system can protect nerve cells against degeneration and also help in recovery (spinal nerve regeneration) following CNS trauma (such as back injury).
Proneuron expertise in neuroimmunology and cell therapy has resulted in a wide patent protection.

Comprised of the brain, spinal cord and optic nerves, the central nervous system (CNS) contains an intricate network of interconnecting neurons that gives rise to sensation, movement control, intelligence, creativity, emotion, learning, thought, consciousness, and memory. Humans are born with all the nerve cells they will ever have and subsequently lose neurons at a slow rate throughout their lives. Depending on their position, loss of neurons to disease or injury can lead to permanent severe disability such as blindness, paralysis, mental impairment, etc.
The spinal cord contains ascending and descending tracts of nerve fibers (axons) to transfer sensory information from the periphery to the brain and motor activities from the brain to the periphery. When the spinal cord is damaged, neural function below the level of the injury is lost. Thus, injuries lower down may affect only the legs, while higher injuries affect the arms and sometimes even the vital systems such as respiration.

The body routinely employs the immune system to protect against intruding microorganisms (such as bacteria and viruses) by attacking and eliminating them. Traditionally, it was believed that protecting the body against harmful self-compounds, which cause nerve degeneration in acute and chronic conditions, was not part of the immune system's function and that immune cell activity may further exacerbate the degenerative process. However, Prof. Schwartz has shown that the natural activity of the immune system can protect nerve cells against degeneration and help in recovery following CNS trauma. Consequently, the immune system may be harnessed to attenuate neuronal loss in diseases such as Amyotrophic Lateral Sclerosis (ALS), Parkinson's disease and glaucoma. The concept of helping the body to "cure" itself (spinal nerve regeneration), offers hope to the millions of victims of nervous system-related disorders.



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Proneuron Biotechnologies is engaged in research
related to spinal cord injuries and paralysis cure.
























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